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The jackson laboratory
The jackson laboratory








the jackson laboratory

Investigations range from developing culture conditions associated with measuring egg development and in vitro fertilization, to piecing together gene pathways in embryogenesis, to the study of senescence (aging) and the onset of disease associated with old age. Fertilization, embryology, and aging are the three broad categories that this work falls into. Unraveling the blueprint for mammalian development from conception to death is the focus of several research groups. Research projects to elucidate the genetic basis of tumorigenesis and metastasis are also underway. Cancer studies at the Laboratory range from investigating basic immunological pathways and their connection with the disease to exploring specific models of cancer, including cervical, mammary, ovarian, liver, and prostate cancers as well as leukemia, and conducting AIDS research.

the jackson laboratory

Integral to studying cancer is the complex field of immunology, or the study of the biological system responsible for fighting disease. Kenneth Paigen became the current director in 1989.Ĭharacterizing the genetic aspects of cancers and tumor growth remains a research focus today. Prehn served as the next director (1976–1980), followed by Dr. Little was succeeded as director of The Jackson Laboratory by Dr. Other research milestones at The Jackson Laboratory include the first demonstrated link between viruses and cancer, with identification of the mouse mammary tumor virus (MMTV) transmitted in the milk of nursing mice the first experimental animal model ( ob mouse) for study of obesity-related diseases the first use of bone marrow transplants to cure a blood disease identification and cloning of the cpe fat mutation in mice discovery and cloning (with collaborators) of the tubby ( tub) mutation and location of the ATHS gene that predisposes a person to atherosclerosis.ĭr. George Snell shared the 1980 Nobel Prize in Physiology or Medicine for this pioneering work, which led to successful organ and tissue transplantation in humans and increased understanding of immune diseases. One such discovery in the 1940s was the MHC (major histocompatibility complex), a critical set of genes that determines the ability of our immune systems to respond to foreign antigens such as infectious viruses. Over the years, many Jackson researchers have been recognized for outstanding contributions to science. World-class research and scientific achievements are hallmarks of the Laboratory. Largely as a result of The Jackson Laboratory’s own research and its commitment to providing unique, quality resources to the community, the mouse has become the primary experimental system for mammalian genetics research. These genetically identical mice are a mainstay of mammalian genetics research, permitting many different scientists around the world to study the same biomedical problems by using identical strains of mice.

the jackson laboratory

The first inbred strains of mice were developed by Dr. By using mouse models that have been discovered as natural mutations or developed through advanced genetic engineering techniques, scientists can determine the functions of disease-causing genes and evaluate potential therapies and cures for human ailments such as cystic fibrosis, AIDS, epilepsy, diabetes, Huntingdon’s disease, atherosclerosis, glaucoma, hypertension, and Down syndrome. Knowledge of the location and function of mouse genes can be correlated with defective human genes that cause disease. Mice and humans suffer from many of the same diseases and have similar genes and gene locations. Little was a genetics pioneer who recognized that the study of hereditary characteristics in mice could help solve human health problems. Jackson, head of the Hudson Motorcar Co., a prominent summer visitor to Bar Harbor who helped fund the facility.ĭr. The new Laboratory was named for Roscoe B. Little left Michigan in 1929 to fulfill his dream of building a year-round genetics research institution in Bar Harbor. He continued the popular course after joining the University of Michigan as president in 1925. Little started a summer field course for the university’s biology students amid the coastal splendor of Bar Harbor.

the jackson laboratory

In 1924, during his tenure as president of the University of Maine, Dr. The Jackson Laboratory was founded by Harvard-trained geneticist Clarence Cook Little.










The jackson laboratory